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Mechanisms of Steatosis-Derived Hepatocarcinogenesis: Lessons from HCV Core Gene Transgenic Mice Review
Pan Diao, Fangping Jia, Xiaojing Wang, Xiao Hu, Takefumi Kimura, Takero Nakajima, Toshifumi Aoyama, Kyoji Moriya, Kazuhiko Koike, Naoki Tanaka
Engineering 2021, Volume 7, Issue 12, Pages 1797-1805 doi: 10.1016/j.eng.2021.08.019
Hepatitis C virus (HCV) is a major cause of chronic hepatitis, liver cirrhosis, and hepatocellularAmong the structural proteins of HCV, the HCV core protein has the ability to regulate gene transcriptionTransgenic mice carrying the HCV core gene exhibited age-dependent insulin resistance, hepatic steatosisIn this review, we summarize the findings obtained from mouse models transgenic for the HCV genome, withinduced by the HCV core protein and the impact of dietary habits on steatosis-derived HCC development
Keywords： Steatosis Hepatocellular carcinoma Trans fatty acid Saturated fatty acid Dietary restriction HCV
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